INFO Coronavirus COVID-19

I can’t thank you enough for the work you do and for helping people to understand the basic functions of the body and it sells I look forward to seeing more of your videos to help educate me more

Note that Glutathione peroxidase requires selenium, glutathione reductase requires ribiflavin
Selenium enriched foods can increase glutathione peroxidase activity

Wow. So after I heard this video I googled superoxide dismutase and Arbs. I found an article in Hypertension Research number 34. 1302-1308 (2011) titled « Reduction of circulating superoxide dismutase activity in type 2 diabetic patients with microalbuminuria and its modulation by telmisartan therapy ».
They found that telmisartan therapy is superior to another ARB (losartan) in reducing oxidative stress and in upregulating superoxide dismutase and discuss why. Check it out, Dr. Seheult.

Excellent review/exposition, many thanks. I now have another justification for my new found love of pineapple juice: manganese source. Wouldn’t mention this if I wasn’t outside the country now, as any consensus acceptance of it would lead to shortages in the stores, hah. I had previously learned another interesting aspect of HO*, that being an extremely short half life of double digit nanoseconds as I can recall. A while back I took SOD and its precursor supplementation but came to doubt it survives long enough in the body to do any good. Insight from this review though gives me a reason to suspect Metformin aids off-label in reduction of inflammation by reducing oxidative stress due to blood glucose surges and excesses: it reduces ability of liver to produce and release glucose into blood during the nighttime sleep cycle. Now as long as doctors don’t scoop up all available supply those diabetics who rely upon it will continue to have access.

As with other relatively unfamiliar information steeped in specialize and unfamiliar language I will need to rewatch the video several times. Not nearly as difficult though as getting through my current section of molecular biology study focused on homologous and non-homologous recombination. Retention is very difficult for me unless I dwell for hours on each page over several days. Thanks for presenting a simplified (low entropy) summary here of oxidative stress.

AMAZING!!!! With this update not only i understand the pathophysiology of this virus but also learn biochemistry which i hated for a long time. Keep up the good work Medcram! Furthermore, it is obvious that SARS-CoV 2 infects the endothelial cells. So is it possible that symptoms of COVID 19 such as thromboembolus or vasculitis be due to the destruction of endothelial cells by T cells and the subsequent inflammation? Of course this in combination with the ACE2 knockout.

Taurine seems interesting……it effects ACE2……….
. https://www.ncbi.nlm.nih.gov/pubmed/28849507?fbclid=IwAR3vw17-hAR_yDAUQ175QRmOwDrdlm5Lmt69XWsiXfPLSVSdpdquDV65jgc

What does this mean for ACE inhibitors which upregulate ACE2 receptors-if you have more ACE2 receptors perhaps this provides some protection again Covid-19?

Really fun speedy refresher course in some basic microbiology and biochemistry! And of course the application to this disease is very interesting.
One question jumps out for me: would younger (50s, say) people who suffer milder (untreated) rheumatoid arthritis also be more vulnerable to COVID-19? All the relevant factors seem to be there…

Tested positive for COVID19 one month ago – I have noticed several things in the last few weeks in relation to my vascular system – discolored breast tissue (currently breastfeeding), pain in inner thighs, flushing face, easily bruising, pain in calves, feet, and groin, also a lot of joint pain. Are there certain supplements that I could be taking to help my body avoid damage?

Very interesting hypothesis. You would think according to your described mechanism that patients with COVID-19 would be more prone to developing inflammatory conditions such as atherosclerosis. Also you could also infer that ACE inhibitors which ramipril and perindopril (which are non-selective for either forms of ACE) would also be prone athero. Do you have any evidence to suggest this?

Thank you for all that you do. I was wondering if you could re visit remdisivir. It seems that in America it is a good drug, but in Canada they say it is not effective. I am a little confused by this. Which country is right? Both have studies to back this up
So confused.
As always keep up the great work, and I hope you get to rest soon. If you were advising the USA government, I would have more confidence in their findings.

Proudly ����

Stay safe,be well

Why does super oxide dismutase not work when your obese? or is it working but but the fattys are so busy stuffing their faces with donuts that SOD is already working overtime 24/7 cause so many superoxides are being created due to excess electron creation?
i really need to lay off the sugar, god damn i wish it wasn’t so tasty!

Where are all these young people dying from strokes etc.? If you have hundreds of thousands or millions of patients you can’t possible know the sources of everything that is going on. There are simply too many factors that are too confusing and and it is simply too hard to track what is going happening on individual cases. You need to have the correct data and you nee to know the date is correct. In Austraia where both of those factors are present there have been zero deaths of anyone under 40 years old out of nearly 7000 reported cases. There are only 90 deaths total out of a 25million population with the medium age of 80 years old. So there seems to be a very distinct difference between this stroke and heart problem thing and the facts. What about overweight, diabetes and preexisting conditions being a factors. Or maybe the way the treatment is being delivered is responsible for the deaths of the young. And finally what are the actual stats on this « young are dying » report. Australia does seem to have a better record than other countries on the the treatment and recovery of the disease and that data indicates would indicate that the « young are dying » theory is bunk. So Doctor tell me how I am wrong if you can. In Australia that stats are 25 million population – 6746 confirmed cases – 5685 recovered and 90 deaths. Youngest victim was 42 years old the median ages is of deaths is 80 years old. To put that in perspective in this conversation if you are under 50 in Australia the chances of dying are one in 25 million. So tell me how I am wrong here Doctor. What is really going on in the USA and the rest of the World? Things that make you go Hmmmm.

With this understanding of clotting, what implication does this have in regards to blood type? If O blood type is slower to clot, would that imply that they are less likely to suffer from these complications?

Is this along the same lines as what the Italian doctor suggested weeks ago?:-

Bologna – From social media comes good news about the Coronavirus, perhaps a solution, which has scientific foundations and is spread by an authoritative doctor from Rizzoli of Bologna, Sandro Giannini. His is a highly qualified curriculum: Full Professor of Orthopedics and Traumatology and of Physical Medicine at the University of Bologna since 1989, director of Clinic I at the Rizzoli Orthopedic Institute and of the Gait Analysis Laboratory, partner in European projects and in national and international research programs, author of more than 600 presentations at national and international conferences and more than 400 articles in Science Citation Index journals. His message gives great hope. Let’s read:

“I don’t want to seem overwhelming to you, but I think I’ve demonstrated the cause of coronavirus lethality. Only at Blessed Matthew are there 2 cardiologists who turn over 150 beds to do echocardium with enormous effort and one is me. Terrible fatigue! However, of what some supposed, but could not be sure, we now have the first data. People go to resuscitation for generalized venous thromboembolism, especially pulmonary. If this were the case, resuscitations and intubations are of no use because first of all you have to dissolve, indeed prevent these thromboembolisms. If you ventilate a lung where blood does not reach, it is not needed! In fact 9 out of 10 die. Because the problem is cardiovascular, not respiratory! It is venous microthrombosis, not pneumonia that determines fatality!

And why are thrombi formed? Because inflammation, as per school text, induces thrombosis through a complex but well-known pathophysiological mechanism. Then? Contrary to what scientific literature, especially Chinese, said until mid-March, it was that anti-inflammatories should not be used. Now in Italy anti-inflammatories and antibiotics are used (as in the influences) and the number of inpatients collapses. Many deaths, even 40 years old, had a history of high fever for 10-15 days that was not treated properly. Here the inflammation destroyed everything and prepared the ground for the formation of thrombi. Because the main problem is not the virus, but the immune reaction that destroys the cells where the virus enters. In fact, our COVID departments have never entered patients with rheumatoid arthritis! Because they make cortisone, a powerful anti-inflammatory!

Therefore, hospitalizations in Italy are decreasing and it is becoming a disease that is treated at home. By taking care of it well at home, you avoid not only hospitalization, but also the thrombotic risk. It was not easy to understand it because the signs of microembolism have faded, even at the echocardium. But this weekend I compared the data of the first 50 patients between those who breathe badly and those who don’t and the situation appeared very clear. For me you can go back to playing and reopen the business. Quarantine street. Not now. But time to publish this data. Vaccine can arrive calmly. In America and other states that follow the scientific literature calling for NOT to use anti-inflammatories, it’s a disaster! Worse than in Italy. And they are old and cheap drugs. « 

Thank you so much for your wonderfully informative videos, you should receive an award for your contributions. Could you please cover the views of Dr. John Ioannidis and Dr. David Katz? They have suggested it may be time to “open up” with a careful, data driven, risk stratified approach. I realize this is a politicized topic which you may like to avoid.

-your friendly fourth year medical student and future radiologist

as the articles and videos began talking about the clotting, etc….it sounded so familiar. recalled a DIC lecture in a mother/baby (obstetrics) class in Nursing school.

⛔I hope countries now have learned the following the hard way after the Wuhan Coronavirus:
1- Stop giving visas to Chinese nationals as long as Ccp is in charge of China.
2- Move manufacturing to your countries.
3- Stop Buying Made in China ⛔

This was amazing, thank you Dr Seheult! I was wondering something – wouldn’t the oxides, which as you mentioned are produced by the body when combating disease (in a controlled fashion) be also harmful to the virus? If it’s toxic to everything around it, wouldn’t the excessive amounts be equally harmful to the virus?

Could you please include Australia and New Zealand in your next video? I must admit I am shocked at how much the worldwide scientific community keeps ignoring such DRAMATIC and ACCURATE and important information. And the best thing about our two countries is — our data is VERY pedantically collated, and VERY carefully accurate. Why not use two countries with such accurate data

OK… so your analysis is great. But is there anything that a person can do, without taking medications, to prevent what you’re describing in your lecture? In other words, its great that we can map this out in a chemical diagram, but how does this help the person that is either trying to prevent Covid-19 or trying to keep it from killing them once infected? Thanks you.

This would explain why HCQ works if used early. It fights inflammation. All this fear mongering causes cortisol to dump in the blood stream throughout the whole body. Inflammation spikes. Explains the long incubation period.

Is the cycle different for a person who is on a keto diet? The energy cycle should be different.
« Compared to glucose metabolism, ketone metabolism produces fewer reactive oxygen species »
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4124736/
A google search finds this https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5012517/
Ketogenic diet decreases oxidative stress and improves mitochondrial respiratory complex activity
Searching ketogenic napdh brings up a bunch of articles
Nutritional Ketosis Increases NAD+/NADH Ratio in Healthy Human Brain
And I have no idea how to evaluate the description of these electron carrier interactions in this article https://www.frontiersin.org/articles/10.3389/fnut.2019.00063/full

HaHa circle K, super presentation, can’t wait for your next one. I remember U of M was doing a Losartan trial on COVID-19.

Wow, not good. I read in a study that ppl with an ACE2 deficiency (elders, those with hypertension, diabetes, obesity,) are the ones ending up with more severe complications and that administration of soluable recombinant ACE2 could be a promising therapeutic approach but requires immediate research.

seems like a great case for high dose vitamin c since vitamin c especially in high dose IV form is a powerful antioxidant

The evidence that this virus actually infects the vasculature is scarce, combined with the fact that SARS-1 did not infect blood vessels, refer the discussion in Hamming et al, 2004 for a discussion on SARS-1 ( https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167720/). In all likelihood, the virus needs other co-receptors besides ACE2 to enter cells, i.e. ACE2 is necessary but not sufficient for infection.

The only decent source I can find explicitly showing viral association with the endothelium is https://doi.org/10.1016/S0140-6736(20)30937-5, and even here they show this only in the kidney, not more generally in major blood vessels. Without evidence that SARS-CoV-2 can directly infect blood vessels this theory makes little sense.

This is true medicine at work. And it’s gives what an “airport” ban in a country still can’t stop the foreign invasion as facemask to lungs because the end target is at ACE II “port” from “oxidative” stress.

Since loss off ACE2 is caused by this virus why isn’t recombinant ACE2 being used for treatment?
World renowned immunologist shows how this works: https://youtu.be/jAW6VBWTiAA
Also seems like it is available for purchase online from multiple sites.

I’ve watched quite a few of your videos, and I have to say, this is one of my all-time favorites. Wonderfully clear and articulate. Thank you!

Continued from previous post, Melatonin is an inhibitor of NADPH Oxidase too! When you combine all of these effects in humans of Covid-19 into a list and compare that list to the known positive health effects of melatonin, it begs the question, why are doctors not suggesting melatonin to their Covid-19 patients. It is an over the counter supplement with a very good safety profile that is probably better than every drug currently being tested and it matches up well against this virus and has a rapid onset of action!

Would fasting by infected patients be worthwhile to do? I heard that major fat metabolism during fasting is done by the liver, which produces ketones, which is distributed by the circulatory system. Would the Kreb Cycle still be used in the metabolism of ketones to ATP?

Vitamin D receptor down regulation. It’s a culprit in cancers and immune disorders and caused by lifestyle and /or several medications side effects.
Using a VDR agonist might work, perhaps, but use of vitamin D supplements when a person has already begun the cytokine storm appears perhaps even harmful.
I’ve been advocating for vitamin D deficiency screening for COVID protocols, but it’s one piece of a puzzle. Downregulation of a receptor is caused by many things from diet/ lifestyle choices to medications… Or maybe even a virus.
There’s a « protocol » from Marshall of the Autoimmunity Research Foundation that addresses this using olmesartan.
Worth considering. I tried emailing him:).

So basically deny CV19 from hurting the ACE2 and the chain reaction does not follow. HCQ+Zn+AZT+Ivermectin should be taken in low doses as a preventive (Zn upto 50mg/day should be ok).

Amazing the way you describe hard to understand science and medicine and you give access to regular people understanding of what is happening and all that live as it unfolds. Always good to explore other avenues and see if this could ultimately be a solution. You are truly a great doctor and a great teacher. Salutations de Montréal.